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Thrombotic thrombocytopenic purpura
Introduction:
Thrombotic thrombocytopenic purpura (TTP) is one of the most devastating thrombotic disorders of humans and carries a mortality rate of about 90% if untreated. Thrombotic thrombocytopenic purpura (TTP) is characterized by thrombocytopenia, microangiopathic hemolytic anemia (MAHA), and microthrombi in multiorgan systems. (6)
MAHA is a hemolytic anemia that results from mechanical shearing (fragmentation) of RBCs as they pass through platelet-rich microthrombi in the microvasculature; it is documented by the finding of prominent schistocytes, including helmet cells and triangular cells, on the peripheral blood smear .Polychromasia (consistent with reticulocytosis) is common. Microspherocytes and nucleated RBCs may also be seen, but microspherocytes are more prominent in patients with warm autoimmune hemolytic anemia and many nucleated red cells may suggest a myelophthisic process, such as metastatic malignancy, that may mimic the clinical features of TTP. (7)
TTP is a medical emergency that is almost always fatal if appropriate treatment is not initiated promptly. With appropriate treatment, survival rates of up to 90 percent are possible.TTP can be acquired, due to an autoantibody inhibitor, or hereditary, due to inherited mutations in ADAMTS13. (7)
Here are some resources to help with exploring the topic thrombotic thrombocytopenic purpura (TTP) and overview of its diagnostic checklist by defining the laboratory role in it's diagnosis.
Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi. TTP results from a sev...
Microangiopathic hemolytic anemia /TTP Peripheral Blood smear
Red Cell: Microangiopathic Hemolytic Anemias of Thrombotic thrombocytopenic purpura
Red cells are "sheared" resulting in a variety of fragmented forms: a triangulocyte ; a nucleated red blood cell with the fragmented red cells and spherocytic. As Schistocytes have an irregular shape, lack the area of central pallor usually seen in erythrocytes.
Diagnosing and Managing TTP: Supporting Implementation of ISTH Guidelines
This engaging interactive platform covers
What is TTP? TTP Signs and Symptoms and How to Confirm and Manage Patients with TTP.
All kind of learner will get beneficial from it since it incorporates video, interactive activities and brief notes for reading .
Hematology Case Study: Thrombocytopenia in a 50 Year Old Male
A 50 year old male patient receiving chemotherapy for treatment of gastric cancer presented to ER. Labs reported: WBC = 5.4 x 103/μL Hgb = 8.9 g/dL PLT (impedance) = 26 x 103/μL PLT-F (fluore…
Haematology_Memory match
You have a limited time to match the terms to their definition. Peripheral smear markers of microangiopathic anemia included. Every time you do the activity, you will have some new terms included. Good luck !
👉Note: Review Questions.
1. List characteristics of thrombotic microangiopathy (TMA)
2. Ideally the diagnosis of TTP is based on___________ deficiency. List some laboratory studies for suspected TTP.
3.What characteristic are seen on examination of the blood smear of patient with TTP?