Resources
Factor V Leiden
Introduction:
The disorder Factor V Leiden is the mutation form of protein Factor V which leads to an increase risk of developing a blood clot. The protein Factor V is necessary in the blood for normal clotting when an injury occurs. Since this disorder is an inherited condition meaning that it is passed on from your parents (one copy of each gene from both parents), it is important that family history is taken into account. Factor V Leiden (also a form of thrombophilia) is also one of the most common inherited mutations which is important to understand as it is a serious disorder that can be life-treating. Remember do not get mixed up between Factor V deficiency and Factor V Leiden as they are completely different.
Here are some resources explaining the concepts of Factor V Leiden, including the clinical characteristics and how it is diagnosed in a haematology laboratory:
Factor V Leiden Thrombophilia- Diagnosis, testing and medical treatment
Materials about factor V Leiden which includes the diagnosis, treatment and additional resources for further information.
Factor V Leiden Thrombophilia- PubMed
Description of Factor V Leiden thrombophilia including further explanation on the clinical characteristics, management of treatments and the genetic aspects related to the disorder.
Factor V Leiden (blood clotting) Video
An in-depth explanation of factor V Leiden that explains the clotting stages that occur. The end of the video shows a visual representation of the differences between normal blood compared to Factor V Leiden in blood.
A 20-year-old woman has died from a blood clot after taking the pill.
Case study of a 20-year-old that passed away form a blood clot. Talks about how the women had an undetected Factor V Leiden mutation, which is known to cause pulmonary embolism. Furthermore, discusses the effects that contraceptive pills have in increasing the risk of blood clots.
Factor V Leiden- Activity
Explore the genetic aspects related to Factor V Leiden. This link is used to as a reference to help complete the activities.
References:
Genome.gov. 2020. About Factor V Leiden Thrombophilia. [online] Available at: <https://www.genome.gov/Genetic-Disorders/Factor-V-Leiden-Thrombophilia> [Accessed 24 September 2020].
2020. [online] Available at: <https://www.youtube.com/watch?v=BaKncL-f2bI&t=1s> [Accessed 25 September 2020].
Cosmopolitan. 2020. A 20-Year-Old Woman Has Died Of A Blood Clot After Taking The Pill. [online] Available at: <https://www.cosmopolitan.com/uk/body/health/a10306051/abbey-parkes-died-blood-clot-contraceptive-pill-factor-v-leiden/> [Accessed 25 September 2020].
Blood Clots. 2020. Factor V Leiden | Blood Clots. [online] Available at: <https://www.stoptheclot.org/learn_more/factor-v-leiden-2/> [Accessed 24 September 2020].
JL, K., 2020. Factor V Leiden Thrombophilia. [online] PubMed. Available at: <https://pubmed.ncbi.nlm.nih.gov/20301542/> [Accessed 23 September 2020].